Journal Title or Book Title
The usage of herbal incenses intentionally doped with synthetic cannabinoids has caused an increase in medical incidents and has triggered legislation to ban these products throughout the world. Law enforcement agencies are experiencing sample backlogs due to the variety of the products and the addition of new and still-legal compounds. In our study, proton Nuclear Magnetic Resonance spectroscopy (NMR) was employed to promptly identify the synthetic cannabinoids after their rapid, direct detection on the herbs and in the powders by Direct Analysis in Real Time-Mass Spectrometry (DART-MS). Compared to conventional lengthy pre-NMR sample clean-up and purification, a simple sample preparation protocol was employed on 50 mg of herbal product samples for quick NMR detection. The combined DART-MS and NMR methods can be used to quickly screen synthetic cannabinoids in powder and herbal samples. Subsequently rapid quantification of cannabinoids can be achieved with short proton-NMR scans when an internal standard, maleic acid, is employed.
Marino, Michael A. Ed.D.; Cody, Robert B.; Dane, A. John; and Huang, Ling, "Rapid Screening and Quantification of Synthetic Cannabinoids in DART-MS and NMR Spectroscopy" (2016). Faculty Works: Biology, Chemistry, and Environmental Studies. 23.